Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Pyrimethanil | 53112-28-0 | 99.9% | 200 MG
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Pyrimethanil is an anilinopyrimidine and a broad-spectrum contact fungicide. It is used to control Botrytis species on various crops by inhibiting methionine biosynthesis in Botrytis cinerea. This compound is suitable for research aimed at preventing fungal diseases in fruit, vegetable, and ornamental plants with mold infections.
- Inhibits methionine and other amino acids biosynthesis in Botrytis cinerea.
- Aids research into preventing fungal diseases on fruit, vegetable, and ornamental plants.
- Decreases polygalacturonase, cellulase, proteinase, and laccase activities.
- Molecular weight: 199.25.
- Molecular formula: C12H13N3.
- Appearance: White to off-white solid.
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Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.8% | 1 G
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Acotiamide monohydrochloride trihydrate is an orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor with an IC50 of 1.79 μM. It can enhance gastric contractility and accelerate delayed gastric emptying. It has potential for research into functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory conditions.
- Orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor
- Enhances gastric contractility and accelerates delayed gastric emptying
- Potential for research of functional dyspepsia and intestinal inflammatory conditions
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Medchemexpress LLC CLIP (86-100) | 648881-58-7 | 98.5% | 1674.10 | 1 MG
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CLIP (86-100) is a fragment consisting of amino acids 86 to 100 of the class II-associated invariant chain peptide (CLIP). This small self-peptide is a cleavage product of the invariant chain and resides in the HLA-II antigen binding groove, playing a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site.
- Consists of amino acids 86 to 100 of the class II-associated invariant chain peptide
- Plays a critical role in the assembly and transport of MHC class II alphabetaIi complexes
- Purity of 98.49%
- Molecular weight: 1674.10
- White to off-white solid appearance
- Soluble in H2O at ≥ 100 mg/mL
- Store as powder at -80°C for 2 years or -20°C for 1 year
- Store in solvent at -80°C for 6 months or -20°C for 1 month
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Medchemexpress LLC Floxuridine | 50-91-9 | 99.97% | C9H11FN2O5 | 200 MG
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Floxuridine is a pyrimidine analog and an oncology antimetabolite. It inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating ATM and ATR checkpoint signaling pathways. Floxuridine is a potent inhibitor for S. aureus infection and induces cell apoptosis, in addition to having antiviral effects against HSV and CMV.
- Inhibits Poly(ADP-Ribose) polymerase
- Induces DNA damage by activating ATM and ATR checkpoint signaling pathways
- Acts as a potent inhibitor for S. aureus infection
- Induces cell apoptosis
- Shows antiviral effects against HSV and CMV
- Potentiates the sensitivity of ovarian cancer cells when co-exposed with PARP inhibitors
- Causes G1/S-phase arrest in ovarian cancer cells
- Reduces the virulence of Staphylococcus aureus
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Medchemexpress LLC AT9283 | 896466-04-9 | 99.7% | C19H23N7O2 | 200 MG
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AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I), and Flt3 (IC50s 1-30 nM). It has been shown to inhibit the growth and survival of various solid tumors both in vitro and in vivo. This product is intended for research use only.
- Potent multi-targeted kinase inhibitor
- Active against Aurora A/B, JAK2/3, Abl (T315I), and Flt3
- Inhibits growth and survival of various solid tumors
- Induces polyploid phenotype and apoptosis in certain cancer cell lines
- Shows significant tumor growth inhibition in xenograft models
- Enhances survival in mouse xenograft models of mantle cell lymphoma
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Apexbio Technology LLC Olmutinib (HM61713, BI 1482694) 1353550-13-6 200mg
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Olmutinib (HM61713 BI 1482694 CAS 1353550-13-6) is an irreversible mutant-selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase It covalently binds to a cysteine residue near the EGFR kinase domain particularly targeting mutant forms such as L858R/T790M and exon 19 deletion In cellular assays Olmutinib demonstrated potent inhibition of EGFR signaling in NSCLC cell lines H1975 (L858R/T790M GI50 9 2 nM) and HCC827 (exon 19 deletion GI50 10 nM) while showing low activity against wild-type EGFR cell lines It exhibits prolonged inhibitory effects ( 24 h) on EGFR activity and demonstrates in vivo antitumor efficacy in xenograft models without significant adverse effects Olmutinib serves as a tool for studying third-generation EGFR TKI resistance mechanisms in NSCLC
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Medchemexpress LLC Matrine | 519-02-8 | 98.0% | 248.37 | 200 MG
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Matrine (Matridin-15-one) is an alkaloid found in plants of the *Sophora* genus. It acts as an agonist for kappa opioid receptor and u-receptor, and exhibits a range of pharmacological properties, including anti-cancer, anti-oxidative stress, anti-inflammatory, and anti-apoptosis effects. It holds potential for research into diseases such as human non-small cell lung cancer, hepatoma, papillary thyroid cancer, and acute kidney injury (AKI).
- Acts as a kappa opioid receptor and u-receptor agonist.
- Demonstrates anti-cancer effects.
- Possesses anti-oxidative stress properties.
- Exhibits anti-inflammatory effects.
- Has anti-apoptosis effects.
- Potential for research in human non-small cell lung cancer, hepatoma, papillary thyroid cancer, and acute kidney injury (AKI).
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Medchemexpress LLC Oridonin | 28957-04-2 | 99.9% | 364.43 | 200 MG
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Oridonin is a diterpenoid isolated from *Rabdosia rubescens*. It acts as an inhibitor of AKT, with IC50s of 8.4 μM for AKT1 and 8.9 μM for AKT2. Oridonin also exhibits anti-tumor, anti-bacterial, and anti-inflammatory effects. It is intended for research use only.
- Inhibits AKT1 (IC50: 8.4 μM) and AKT2 (IC50: 8.9 μM)
- Exhibits anti-tumor effects
- Exhibits anti-bacterial effects
- Exhibits anti-inflammatory effects
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Apexbio Technology LLC U0126 200mg
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U0126 (CAS 109511-58-2) is a selective non-ATP competitive inhibitor of the MAPK/ERK kinase (MEK1/2) pathway interfering with downstream ERK1/2 activation By inhibiting MEK1/2 activity U0126 modulates cellular processes including proliferation differentiation and survival Additionally U0126 has been reported to suppress autophagy and mitophagy pathways This compound is widely used in biomedical research to investigate MAPK signaling dynamics as well as to explore the regulation of autophagic and mitochondrial quality control mechanisms in various cell models
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eMolecules 101066-61-9 | 2-chloropyridine-4-carbaldehyde | Pharmablock | MFCD06651557 | 141.550 | C6H4ClNO | 97.000 | Clc1cc(C=O)ccn1 | 2.5g | 686925096
2-chloropyridine-4-carbaldehyde | Pharmablock | 101066-61-9 | MFCD06651557 | 141.550 | C6H4ClNO | 97.000 | Clc1cc(C=O)ccn1 | 2.5g | 686925096
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Apexbio Technology LLC Oxymatrine 16837-52-8 200mg
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Oxymatrine (CAS 16837-52-8) is a quinolizidine alkaloid extracted from Sophora flavescens It has been shown to modulate multiple cellular pathways associated with fibrosis and neurodegeneration including inhibition of TGF- 1-mediated signaling and reduction of pro-inflammatory cytokine expression Oxymatrine exhibits antifibrotic and neuroprotective properties in various experimental models It is also extensively studied for its antiviral activity against hepatitis B virus and has been applied in traditional Chinese medicine for hepatitis management This compound is valuable for investigating mechanisms of fibrosis neuroprotection and viral pathogenesis
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Medchemexpress LLC Foliglurax monohydrochloride | 2133294-96-7 | MFCD31807615 | 98.6% | 457.97 | 100 MG
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Foliglurax monohydrochloride is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM), with an EC50 of 79 nM. It exhibits an antiparkinsonian effect.
- Highly selective and potent
- Brain-penetrant
- Metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM)
- EC50 of 79 nM
- Exhibits an antiparkinsonian effect
- Chemical formula: C23H24ClN3O3S
- Appearance: Solid
- Color: Light yellow to yellow
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Medchemexpress LLC Piperacillin sodium | 59703-84-3 | 98.22% | 200 MG
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Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic that exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. It is most commonly used in combination with the β-lactamase inhibitor Tazobactam.
- Exhibits potent bactericidal activity
- Effective against Gram-negative bacteria
- Effective against select Gram-positive strains
- Targets penicillin-binding proteins
- Commonly used with β-lactamase inhibitor
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Medchemexpress LLC Chlorcyclizine hydrochloride | 14362-31-3 | 99.8% | 337.29 | 200 MG
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Chlorcyclizine hydrochloride is a histamine H1 antagonist. This product is a solid with a white to off-white appearance.
- Has a purity of 99.77%.
- Soluble in DMSO at 77.5 mg/mL.
- Targets the histamine H1 receptor.
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Medchemexpress LLC MSA-2 | 129425-81-6 | 99.8% | 294.32 | 200 MG
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MSA-2 is a potent and orally available non-nucleotide STING agonist that binds to STING as a noncovalent dimer with nanomolar affinity. It stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.
- Potent and orally available non-nucleotide STING agonist
- Binds to STING as a noncovalent dimer with nanomolar affinity
- Stimulates interferon-β secretion in tumors
- Induces tumor regression with durable antitumor immunity
- Synergizes with anti-PD-1 in syngeneic mouse tumor models
- Achieves comparable exposure in tumor and plasma
- Exhibits dose-dependent antitumor activity
- Induces elevations of IFN-β, IL-6, and TNF-α in tumors
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